The first Virtual Conference on Mechanical Fatigue (VCMF 2020) is organised by the University of Porto (FEUP, Portugal), the Wroclaw University of Science and Technology (Poland) and the ESIS/TC12 Technical Committee (European Structural Integrity Society – ESIS), to be held on 9-11 September 2020. This conference is intended to be a forum of discussion of new research concepts, equipment, technology, materials and structures and other scientific advances within the field of mechanical fatigue and fracture. It is expected contributions from engineers, metallurgists, material scientists, among others, allowing a very multidisciplinary discussion.